The mice in the lupus group had significantly poorer cognitive function in seven weeks, tracking the decline in the glutamate / glutamine ratio. Cognitive function, went further deteriorate with age, whereas there was no change in control mice. – This tells us that MRS may be useful for monitoring the disease instead of of time-consuming behavioral studies, he said. The changes in the glutamate / glutamine ratio indicate that the neuropsychiatric lupus is getting worse. School of Medicine.the biochemical changes to neuropsychiatric symptoms in people equate expected future human studies, he said.
His results showed a dramatic decrease in the ratio of two biochemicals, glutamate and glutamine, as indicated by MRS in the mice, measured with lupus compared with control mice as early as seven weeks of life the behavioral tests directly associated. Other biochemical pairs also showed changes, but not as dramatically as glutamate / glutamine. At 11 and 15 weeks, there were significant further decreases in the glutamate / glutamine ratio.. In his study, Mishra is using mice that have a defective gene and spontaneously develop lupus, including lymph node swelling and increased spleen size.Promote the welfare ‘stress management ‘Project Like employee coping with stress the workplace and in their own homes , the focus of Penn State, portion of a $ 35,000 NIH fellowship to test the even, the effectiveness of a workplace assistance for the staff reducing stress and promote well-being.